Comparison of various methods for removing double antibiotic paste from root canal walls during regenerative endodontic therapy

Abstract

ABSTRACT Aim: This study investigated the efficacy of Endoactivator, Pro-agitator tip system (PATS) Vario, BF brush, and dual side-vented needle irrigation to remove double antibiotic paste (DAP) from the root canal. Methods: Biomechanical preparation till size #25 (F2) was carried out utilizing the Protaper Universal System on 92 extracted teeth with single root and root canal. All the canals were filled with DAP for 21 days, and the roots were split into two halves (n = 20) and divided into four groups randomly based on the irrigation method, using either dual side-vented needle irrigation, BF brush, Endoactivator, or PATS Vario. Under a stereomicroscope, the quantity of medication still present at every root half was assessed using a four-grade scoring system. Results: PATS Vario (0.46 ± 0.50) followed by Endoactivator (0.46 ± 0.52) groups were substantially more effective at eliminating DAP from the root canal than BF brush groups (0.98 ± 0.58) and dual side-vented irrigation tips (2.29 ± 0.53) (P < 0.05) However, none of the methods succeeded in entirely removing antibiotic paste from canal walls. Conclusion: PATS Vario Group was more efficient than Endoactivator at eliminating DAP from root canal walls, but the difference was not statistically significant (P > 0.05).