Comparison of Use and Non-Use of Prophylactic Antibiotics for Severe Acute Pancreatitis. Randomized Clinical Trial. Preliminary Report

Abstract

Introduction: Acute pancreatitis is a frequent disease in Chile, with mortality rate of 10-30%. Prophylactic antibiotics administration has been part of severe acute pancreatitis treatment for theoretical prevention of infectious complications and mortality reduction. Yet the available evidence is controversial. The aim of this article is to demonstrate that prophylactic antibiotics do not reduce complications, need for intensive care unit bed or mortality in severe acute pancreatitis.