Comparison of urine uric acid excretion between type 1 and type 2 diabetes

Abstract

To compare the features of urine uric acid excretion (UUAE) between type 1 and type 2 diabetes mellitus (T1DM and T2DM). This observational study was carried out in 234 T1DM and 2898 T2DM subjects. UUAE levels were determined enzymatically from a single 24-h urine collection. The clinical features of UUAE were compared between T1DM and T2DM. The factors influencing UUAE levels were also been analyzed in both T1DM and T2DM subjects, respectively. The levels of UUAE were significantly higher only in the T2DM subjects without chronic kidney disease (CKD) [2887 (2290–3656) μmol/24h] than in the T1DM subjects without CKD [2562 (2053–3253), p < 0.001], but not in the diabetics with CKD (p = 0.233). After controlling for multiple confounding variables, factors including systolic blood pressure, diastolic blood pressure, and 24-h urine sugar excretion obviously related to UUAE levels in T1DM. However, in addition to the above-mentioned parameters, other factors such as age, sex, CKD, diabetic duration, BMI, ALT, SUA, 2h C–P, and HbA1C are also significantly associated with UUAE levels in T2DM. Despite some similarities, the clinical characteristics of UUAE are significantly different between T1DM and T2DM. • The clinical characteristics of urine uric acid excretion (UUAE) are different between T1DM and T2DM subjects. • Only in patients with chronic kidney disease (CKD), UUAE levels were higher in the T2DM subjects than in the T1DM subjects. • UUAE levels between the subjects with and without HU were no significantly different in both T1DM and T2DM subjects.