Abstract
Intralesional 5‐fluorouracil (5‐FU) and triamcinolone acetonide (TAC) injection is effective for the treatment of hypertrophic scar. The side effects of current that recommended 45 mg/ml (high‐dose) 5‐FU have been reported. However, no previous study has investigated the efficacy and safety of low‐dose (2.5 mg/ml) 5‐FU with 4 mg/ml TAC or medium‐dose (10 mg/ml) 5‐FU with 4 mg/ml TAC for treatment of hypertrophic scar. Herein, a retrospective comparative study was conducted. The records of 70 patients, treated with low‐dose (2.5 mg/ml) 5‐FU and 4 mg/ml TAC every 4 weeks (Group 1) or medium‐dose (10 mg/ml) 5‐FU and 4 mg/ml TAC every 4 weeks (Group 2), were analyzed. The Vancouver Scar Scale (VSS), vascularity, and thickness of hypertrophic scar at baseline and at 7th‐treatment (each group received 6 treatment sessions) were compared. The ultrasound showed the large vascular distribution in scar margins. Both groups gained clinical improvement in VSS, vascularity, and thickness. Group 2 (medium‐dose) exhibited significantly better improvement than Group 1 (low‐dose). However, the overall side effects rate was 11.4% in Group 1, significantly lower than 31.4% in Group 2. Scar margins were suggested to be target sites for injection. Medium‐dose (10 mg/ml) 5‐FU + 4 mg/ml TAC could effectively reduce the thickness of hypertrophic scar; however, the side effects rate was also higher in medium‐dose group than in low‐dose group.
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