Abstract
Ansattienin [1], an antifungal antibiotic isolated from Streptomyces collinus, is unusual in that it contains a cyclohexanecarboxylic acid moiety that is derived from shikimic acid. An enoyl CoA reductase catalyzing the conversion of 1-cyclohexenylcarbonyl CoA to cyclohexylcarbonyl CoA reductase was purified to homogeneity, and it is suggested that this enzyme catalyzes the final step in the pathway from shikimic acid to cyclohexanecarboxylic acid, An enzyme catalyzing the conversion of crotonoyl CoA to butyryl CoA was also purified to homogeneity. The stereochemical course of the reactions catalyzed by these two enoyl CoA reductases, together with their physical properties, is discussed in the light of an evolutionary relationship
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