Abstract
Twenty-eight immature permanent incisors in six cynomolgus monkeys were inoculated with Staph-lococcus aureus until they developed periapical lesions. The canals were then cleaned and shaped 1 mm short of the radiographic apices and were either left unfilled or filled with Ca(OH) 2 (pH 11.8) or with CaCl 2 (pH 4.4). The animals were killed at 3 and 6 months postoperatively. The presence or absence of apical bridge formation and the degree of inflammation were investigated histologically. The results indicate that the alkalinity of Ca(OH) 2 may be a significant feature of this substance in its ability to induce hard tissue formation.
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