Abstract
Background/objectivesOptical coherence tomography (OCT) is widely used for evaluation of healing response to stent implantation. We sought to test the agreement between the 1-mm and 0.6-mm sampling intervals for assessment of the percentage of uncovered and malapposed struts by OCT. MethodsThirtyeight patients presenting with acute coronary syndrome were randomized to receive either a titaniumnitrideoxidecoated stent (n=19) or an everolimuseluting stent (n=19). Neointimal strut coverage and strut apposition were evaluated by OCT at 2month followup. Two independent investigators performed offline OCT image analysis at 1mm intervals. One investigator repeated the measurements at 0.6mm intervals and measurements were compared between the two sampling intervals. ResultsAt a median followup of 60 [8] days, 694 crosssections (7603 struts) and 1138 crosssections (12,331 struts) were analysed at 1mm and at 0.6mm intervals, respectively. The median [IQR] percentage of uncovered struts was 3.27% [11.1] versus 3.38% [9.76] (p=0.001), and the mean (±SD) percentage was 7.69±9.99% versus 6.27±8.14% (p=0.004), for the 1mm sampling interval versus the 0.6mm sampling interval analysis, respectively; the median percentage of malapposed struts was 0.42% [2.04] versus 0.12% [1.63], respectively, (p=0.003). The intraclass correlation coefficient between the two observers for the percentage of uncovered struts was 0.95. ConclusionsThe OCT-evaluated strut-level measurements of neointimal healing after stent implantation differ significantly between the 1-mm and the 0.6-mm sampling intervals.
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