Abstract
Background: Midazolam is a water-soluble, short acting benzodiazepine. The objective of our study was to study the effect of two different doses of oral midazolam premedication on propofol induction dose and characteristics.
 Methods: Randomized, prospective, double blind study conducted on 100 ASA I and II patients, falling between the age group of 18-60 yrs were randomly divided in to two groups, group I and group II, who received 7.5mg and 15mg midazolam orally 45 mins before the surgery respectively.
 Results: Mean time taken for induction in group-A was significantly higher in group-I as compare to group-II. No significant difference was noted with respect to degree of sedation, changes in the heart rate and means arterial pressure, oxygen saturation between the two groups.
 Conclusion: Our study concluded that 15mg midazolam premedication offers more benefits than 7.5mg midazolam by reducing induction dose of propofol without any undesirable effects like excess sedation, bradycardia and hypotension.
 Keywords: Midazolam, Induction, Premedication
Highlights
Midazolam is a water-soluble, short acting benzodiazepine used in the emergency treatment of prolonged seizures
The objective of our study was to study the effect of two different doses of oral midazolam premedication on propofol induction dose and characteristics
Randomized, prospective, double blind study conducted on 100 ASA I and II patients, falling between the age group of 18-60 yrs were randomly divided in to two groups, group I and group II, who received 7.5mg and 15mg midazolam orally 45 mins before the surgery respectively
Summary
Midazolam is a water-soluble, short acting benzodiazepine used in the emergency treatment of prolonged seizures. It is classified as a Restricted Schedule 4 drug and is available by prescription only.[1] Anxiety in response to impending surgery is a common emotional phenomenon, but it leads to perioperative physiological and psychological changes. The objective of our study was to study the effect of two different doses of oral midazolam premedication on propofol induction dose and characteristics. Results: Mean time taken for induction in group-A was significantly higher in group-I as compare to group-II. Conclusion: Our study concluded that 15mg midazolam premedication offers more benefits than 7.5mg midazolam by reducing induction dose of propofol without any undesirable effects like excess sedation, bradycardia and hypotension.
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