Comparison of two different doses of dexmedetomidine in attenuation of haemodynamic response during endotracheal extubation

Abstract

The data in the published literature on the use of dexmedetomidine in various dosages during extubation from India is modest. We have compared the effectiveness of intravenous dexmedetomidine 0.5 µg/Kg body weight and 0.75 µg/Kg body weight during endotracheal extubation. Seventy-four patients aged more than 18 years posted for elective surgery under general anaesthesia were included in this randomised double- blind controlled study. Group D1 and Group D2 patients received 0.5 µg/Kg and 0.75 µg/Kg body weight intravenous dexmedetomidine respectively. The primary outcome measures were to compare haemodynamic parameters, whereas secondary outcome measures were to compare extubation quality, and post-extubation sedation. The mean heart rate at reversal, and after endotracheal extubation was considerably elevated in group D1 as compared to D2. The mean systolic blood pressure, diastolic blood pressure and mean arterial pressure after endotracheal extubation were considerably elevated in group D1 as compared to D2. The mean respiratory rate at reversal, and after endotracheal extubation were considerably elevated in Group D1 as compared to Group D2. The mean sedation score after endotracheal extubation was considerably elevated in Group D2 as compared to Group D1. The haemodynamic parameters were better in Group of patients who received intravenous dexmedetomidine 0.75 µg/Kg body weight as compared to Group of patients who received dexmedetomidine 0.50 µg/Kg during endotracheal extubation.