Abstract
The following study was designed to compare the effectiveness of imipramine (Tofranil) and pheniprazine (Cavodil) in the treatment of endogenous depression. Controlled trials have shown the value of imipramine (Holdway, 1960) and therefore no placebo group was included. The theoretical advantages of a cross-over technique were considered to be outweighed by such disadvantages as the tendency for the effects of the first therapeutic agent to continue into the second phase of the experiment; and the tendency for rapid remissions to occur with anti-depressive drugs and to persist for a period despite withdrawal. Thus two similar groups of patients, each treated with full dosage of their respective drugs, were compared. The selection of patients was randomized, and the trial was blind throughout.
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