Comparison of Treated Mean Intraocular Pressure in Stable Glaucoma with Different Severity in Vietnam.

Nguyen Thi Ha Thanh

doi:10.5005/jp-journals-10008-1153

Abstract

ABSTRACTPurpose: To compare stable glaucoma with different severity in a Vietnamese population in regard to mean intraocular pressure (IOP) and number of medications used.Materials and methods: A total of 116 eyes from 68 patients with medically treated glaucoma were prospectively enrolled at a single center and subjected to automated perimetry every 3 months for at least 9 months. Glaucoma progression was identifed according to early manifest glaucoma trial criterion using glaucoma progression analysis software. Eyes in which no progression was identifed were staged for glaucoma severity using field criteria (mild MD ≥ 6 dB, moderate MD –6 to –12 dB, advanced MD ≥ 12 dB, end-stage central island only). Groups were compared in terms of mean IOP and number of medications used. Statistical analysis was performed using SPSS v16.0.Results: A total of 109 eyes displayed no evidence of pro gres-sion during the study period. Pretreatment mean IOP for mild, moderate, severe and end-stage glaucoma was 28.2 ± 1.4, 28.8 ± 1.6, 29.1 ± 1.8, and 28.6 ± 0.8 mm Hg. The mean IOP of all 109 eyes during follow-up was 16.8 ± 1.4 mm Hg (95% conf dence interval = 15.4 ± 18.2 mm Hg). Mild, moderate, advan ced, and end-stage glaucoma had mean IOP of 17.5 ± 1.2, 16.9 ± 1.3, 15.8 ± 0.9 and 15.5 ± 1.1 mm Hg. The mean IOP of mild stage was significantly higher than advanced and end-stage (t-test, p < 0.001). Also, the mean IOP of moderate glaucoma was significantly higher than advanced and end-stage glaucoma (t-test, p < 0.05). Number of medications had no signi ficant difference among these glaucoma stages (chi-square test, p > 0.05).Conclusion: Reached IOP lowering contributes to glaucoma stabilization especially in late stages. To maintain stable glaucoma, there was no difference in medical procedure of glaucoma stages.How to cite this article: Thanh NTH. Comparison of Treated Mean Intraocular Pressure in Stable Glaucoma with Different Severity in Vietnam. J Current Glau Prac 2014;8(1):7-9.

Highlights

Elevated intraocular pressure (IOP) is an important risk factor for the development or progression of glaucomatous optic neuropathy
Many studies have reported on IOP in stable glaucoma and how this was achieved, no studies have exa mined this in a Vietnamese population
The study found that mean IOP was significantly lower in stable advanced or end-stage glaucoma compared to stable moderate glaucoma or stable mild glaucoma

Summary

Introduction

Elevated intraocular pressure (IOP) is an important risk factor for the development or progression of glaucomatous optic neuropathy. IOP reduction is an important strategy to slow or halt glaucoma progression and irreversible visual impairment.[1,2]. First-line medical treatment for lowering IOP is mono therapy with either a topical prostaglandin analog or a β-adrenergic antagonist (β-blocker). Many patients eventually require adjunctive therapy to achieve their target IOP and maintain stable glaucoma.[3]. Many studies have reported on IOP in stable glaucoma and how this was achieved, no studies have exa mined this in a Vietnamese population. The aim of this study was to compare stable glaucoma with different severity in regard to mean IOP and number of medications used

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Results

Discussion

Conclusion