Abstract
Comparison of Toxin Fractions Isolated from Protoscoleces and Hydatid Cyst Fluid of Hydatid Cyst of Sheep in Mosul, Iraq
Highlights
Cystic echinococcosis is a cyclozoonotic disease of global importance (Andersen et al.,1997), caused by the larval stage of the taeniid tapworm Echinococcus granulosus
The present study is a continuation to the above mentioned results in which toxin fractions (TFs) were isolated from protoscoleces (P) and hydatid cyst fluid (HCF) of Echinococcuss granulosus of sheep origin with an ultimate goal of investigating the possibility of existence of some differences in the TFs of these materials isolated from same host but from different batches obtained from more than only one host
The separation of TFs and HCF by thin layer chromatography (TLC) from different batches of liver protoscoleces and HCF of sheep origin indicate the existence of some differences in the number and rate flow of the TFs between protoscoleces and cyst fluid of same host and between protoscoleces obtained from cysts of different sheep, the same was obtained in case of HCF of different sheep host Table (1), Fig. (1)
Summary
Cystic echinococcosis is a cyclozoonotic disease of global importance (Andersen et al.,1997), caused by the larval stage of the taeniid tapworm Echinococcus granulosus These cestodes, like other parasites, develop and survive in an environment which is often hostile to them. The fact that mice, infected with Echincoccus granulosus, develop an acquired immunity, is not suggestive of a model in which hydatid cyst provoke a general and persistent immunosuppression of the host (Janssen et al, 1997). Some of these mechanisms can take the form of immunomodualtion of the host immunity (Lyod and Soulsby, 1988). The above mentioned demonstrations motivated us to investigate the effect of TFs isolated from HCF and P of hydatid cysts of sheep origin as possible immunmodulators in mice prior to infection with secondary hydatid cyst
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