Abstract
AbstractStandardized procedures were developed to compare quantitatively the toxic and transforming effects of ten environment‐related polycyclic aromatic hydrocarbons (PAH's) using early passage mixed cultures of fetal Syrian golden hamster lung cells. Evaluation of toxicity was attempted by applying a linear regression to the relative number of surviving colonies. Transformation data were fitted satisfactorily to the one‐hit model. Used as a monitor compound in each subexperiment, benzo[a]pyrene (BaP) showed dose‐related colony reduction (0.01–0.5 μg ml−1). Benzo[b]fluoranthene (BbF), indeno[1,2,3‐cd]pyrene (IcdP), benzo[k]fluoranthene (BkF) and benzo[e]pyrene (BeP) were generally colony enhancing at dose ranges up to 1.0 μg ml−1. Fluoranthene (FLT), pyrene (PYR), chrysene (CHR), benzo[ghi]perylene (BghiPL) and benz[a]anthracene (BaA) were neither stimulatory nor inhibitory to colony formation. For transformation induction, BaP was over 14‐fold more effective than BbF, IcdP or BaA. The other PAH's showed no transformation.
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