Abstract
Fractional thyroidal and renal radioiodine clearance and renal 127I excretion were measured in 152 euthyroid subjects. Thyroidal 127I accumulation (A) was calculated from the basic formula of Stanbury et al. with short-term thyroidal and extrathyroidal radioiodine clearance measurements substituted for 48-hr thyroidal radioiodine uptake. Appropriate corrections were included for diurnal variations in renal radioiodine clearance, lag time in urine collections, and losses of iodine in uncollected urine and in sweat and stools. Thyroxine 131I degradation (H4) was measured by whole body counting techniques and compared with calculated thyroidal 127I accumulation in 29 subjects on a mean calculated daily iodine intake of 387 μg. Significant negative correlation of thyroidal radioiodine uptake and renal iodine excretion was observed (p < 0.001). The correlation and regression coefficients of these indices were, however, low (0.33 and 0.238). In addition, mean daily thyroidal 127I accumulation exceeded daily thy...
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