Comparison of three methods of treatments in patients with early stage primary gastric diffuse large-B cell lymphoma

Abstract

Objective To compare the therapeutic effects of three therapeutics to earlier primary gastric diffuse large B cell lymphoma(PG-DLBCL). Methods By reviewing a data-base of 66 patients with earlier PG-DLBCL from Aug 2000 to Oct 2011 were enrolled, patients were divided into chemotherapy alone(21 cases), radiotherapy combined with chemotherapy(22 cases) and surgery followed chemotherapy group(23 cases), and to comparing the prognosis of the three therapeutics. Results The complete remission rates(CR) of the three groups was 47.6%, 77.3%, 65.2%(P>0.05). The median progression-free survival(PFS)of the three groups in 66 patients was 61.5, 90.4 and 79.1 months, the radiotherapy combined group was proven to be significantly better than chemotherapy alone group and surgery followed chemotherapy group(χ2=6.726, P 0.05) in 3-year survival rate and 5-year survival rate. Conclusions Radiotherapy combined with chemotherapy can significantly improve the PFS without increasing the risk of other adverse outcomes, and could be the first treatment way for the earlier PG-DLBCL. Key words: Primary gastric diffuse large B cell lymphoma; Early stage; Methods of treatment; Curative effect