Comparison of Three Levels of a Mixture of Sulfadimethoxine and Ormetoprim for Prevention of Fowl Cholera in Turkeys Exposed via the Palatine Sinuses

Abstract

SUMMARY Rofenaid, a mixture of sulfadimethoxine and ormetoprim, at concentrations of 0.04, 0.02, and 0.01% in the feed, was evaluated for control of experimentally induced fowl cholera in turkeys. A different isolate of Pasteurella multocida was used in each of 4 different experiments. Exposure to 3 of the isolates was by injecting P. multocida into the palatine air spaces of the head; with the fourth isolate the palatine cleft was swabbed. Considering together the four isolates of P. multocida used for exposure, Rofenaid significantly (P<0.05) increased livability at both the 0.02 and 0.04% levels, and at the 0.04% level decreased the incidence of torticollis and of skull lesions in survivors. Exposure by injecting isolates from chronic infections into the palatine air spaces was comparable to swabbing the palatine cleft with the isolate from an acute infection.