Comparison of Therapies with GLP1 Analogues in Type 2 Diabetic Patients Without Control

Abstract

BackgroundType 2 Diabetes (T2D) is a chronic disease in the aspect of insulin resistance in the adulthood, that requires continuous medical attention and represents a therapeutic challenge beyond glycemic control. Glucagon-like Peptide-1 receptor analogues (GLP-1) have a favorable effect in modifying cardiovascular risk factors. the objective is to analyze the clinical benefits of there. MethodsComparison of three descriptive, retrospective cohort studies, conducted between June-2013 and June-2016, 52 week follow-up, including patients with uncontrolled T2D, with different therapies, who were added to the treatment GLP-1 analogues, in a high complexity center in the city Cali, Colombia. Three specific therapies where compared: Liraglutide 1.8 mg/day; exenatide 2 mg/week, and exenatide 2 mg/week plus dapagliflozin/metformina 10/2000 mg/day, respectively. Repeated measurements were made over time of glycated hemoglobin (A1C), weight, and blood pressure (BP). ResultsThe mean age was 60.6 years. The onset of T2D was 6.2 years. Combination therapy showed an average decrease of: A1C of 1.8% for Liraglutide (IC 95%, 1.52-2.04; P<0.0001), 1.7% for exenatide (IC 95%, 1.45-1.94, p<0.000) and 0.70% for exenatide plus dapagliflozin/metformin (CI 0.58 to 0.82, p <0.001); weight loss of: 5.1 kg, 5.8 kg and 3.04 kg respectively; and decrease of systolic BP of: 6.7mmHg, 15.6 mmHg and 16.3 mmHg, respectively. The largest decrease in A1C occurred between first and second visit and no serious adverse events were observed. ConclusionGLP-1 analogues are a favorable therapeutic option for patients with uncontrolled T2D, with beneficial effect on body weight and BP with statistically significant results.