Abstract
Streptococcus pneumoniae causes many people to suffer from pneumonia, septicemia, and other diseases worldwide. To identify the difference in susceptibility of and treatment efficacy against S. pneumoniae in three ICR mouse stocks (Korl:ICR, A:ICR, and B:ICR) with different origins, mice were infected with 2 × 106, 2 × 107, and 2 × 108 CFU of S. pneumoniae D39 intratracheally. The survival of mice was observed until three weeks after the infection. The three stocks of mice showed no significant survival rate difference at 2 × 106 and 2 × 107 CFU. However, the lung and spleen weight in the A:ICR stock was significantly different from that in the other two stocks, whereas the liver weight in B:ICR stock was significantly lower than that in the other two stocks. Interestingly, no significant CFU difference in the organs was observed between the ICR stocks. The level of interferon gamma inducible protein 10 in Korl:ICR was significantly lower than that in the other two stocks. The level of granulocyte colony stimulating factor in B:ICR was significantly lower than in the other two stocks. However, tumor-necrosis factor-alpha and interleukin-6 levels showed no significant difference between the ICR stocks. In the vancomycin efficacy test after the S. pneumoniae infection, both the single-dose and double-dose vancomycin-treated groups showed a significantly better survival rate than the control group. There was no significant survival difference between the three stocks. These data showed that Korl:ICR, A:ICR, and B:ICR have no susceptibility difference to the S. pneumoniae D39 serotype 2.
Highlights
Streptococcus pneumonia is a gram-positive pathogen that affects humans [1, 2]
Survival rate examination in the different mouse stocks To identify the survival difference among the three different mouse stocks, the survival rate was measured for 3 weeks after the S. pneumoniae D39 infection
When mice were infected with 2 × 106 Colony forming units (CFU) bacteria, death in all the three stocks began at day 2 after the infection
Summary
Streptococcus pneumonia is a gram-positive pathogen that affects humans [1, 2]. The treatment for infection with S. pneumoniae requires taking antibiotics. This pathogen causes several infectious diseases such as pneumonia, meningitis [3], and acute otitis media [4] and acute sinusitis [5]. The occurrence of pneumococcal and acute respiratory infections is decreasing but is still considerably high in children under the age of 5 and in elders with weak immunity, in developing countries. 20–25% of all mortalities in children are identified to be a bacterial pneumonia caused by S. pneumoniae [4, 6]. The use of antibiotics in the treatment of the disease is impeded by the increase
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