Abstract
Objective This study aimed to explore the value of color Doppler ultrasound and multislice spiral CT (MSCT) in the differential diagnosis of benign and malignant nodules in the liver. Methods The clinical imaging data of 102 patients with nodular hepatocellular carcinoma (hepatocellular carcinoma group) and 50 patients with focal nodular hyperplasia (FNH) of the liver (FNH group) admitted to our hospital were collected, and their color Doppler ultrasound and MSCT imaging features were retrospectively analyzed to explore the value of their clinical application in the differential diagnosis of benign and malignant nodules in the liver. Results The sensitivity, accuracy, and negative predictive value of MSCT in the diagnosis of nodular liver cancer were 94.12%, 92.76%, and 88.24%, respectively, which were significantly higher than those of color Doppler ultrasound 79.41%, 84.21%, and 69.12%, and the difference was statistically significant (P < 0.05). Conclusion In conclusion, the value of MSCT in the differential diagnosis of benign and malignant liver nodules was significantly better than color Doppler ultrasound.
Highlights
IntroductionNodular hepatocellular carcinoma and focal nodular hyperplasia (FNH) are common types of hepatic solid occupancies, which are malignant and benign lesions of the liver, respectively [1, 2], and their diagnosis and differential diagnosis are the basis for rational diagnostic and therapeutic measures [3]. e pathogenesis of nodular hepatocellular carcinoma and focal nodular hyperplasia of the liver cannot be fully explained clinically, and because both lesions are liver lesions with abundant blood supply, the morphological characteristics of the two diseases have certain similarities and morphological features have certain overlap, which make the differential diagnosis of some lesions difficult and increase the difficulty of clinical diagnosis and treatment, making the clinical differential diagnosis more difficult [4,5,6]
Clinical imaging data of 102 patients with nodular hepatocellular carcinoma and 50 patients with focal nodular hyperplasia of the liver (FNH) admitted to our hospital from January 2015 to December 2018 were collected and retrospectively analyzed, and all patients underwent color Doppler ultrasound and Multislice spiral CT (MSCT) before treatment. e study was approved by the Ethics Committee of Jiaozhou Central Hospital, and patients signed an informed consent form to participate in the study on a voluntary basis
Color Doppler Ultrasonography. e patient was placed in a supine position with a morning fast of more than 8 hours, and each section of the liver was carefully scanned by a physician specialized in ultrasound. e liver parenchyma, the bile duct, and portal venous system were observed in a left-to-right, top-down sequence, and the lesion site, morphology, margins, echogenicity, and relationship with adjacent tissues were observed and analyzed
Summary
Nodular hepatocellular carcinoma and focal nodular hyperplasia (FNH) are common types of hepatic solid occupancies, which are malignant and benign lesions of the liver, respectively [1, 2], and their diagnosis and differential diagnosis are the basis for rational diagnostic and therapeutic measures [3]. e pathogenesis of nodular hepatocellular carcinoma and focal nodular hyperplasia of the liver cannot be fully explained clinically, and because both lesions are liver lesions with abundant blood supply, the morphological characteristics of the two diseases have certain similarities and morphological features have certain overlap, which make the differential diagnosis of some lesions difficult and increase the difficulty of clinical diagnosis and treatment, making the clinical differential diagnosis more difficult [4,5,6]. Nodular hepatocellular carcinoma and focal nodular hyperplasia (FNH) are common types of hepatic solid occupancies, which are malignant and benign lesions of the liver, respectively [1, 2], and their diagnosis and differential diagnosis are the basis for rational diagnostic and therapeutic measures [3]. Color Doppler ultrasound and MSCT were used to differentiate nodular hepatocellular carcinoma from focal nodular hyperplasia in the liver and to compare their clinical value in the differential diagnosis of benign and malignant nodules in the liver. We hypothesized that MSCT was more sensitive than color Doppler ultrasound in differentiating nodular hepatocellular carcinoma from focal nodular hyperplasia in the liver
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