Abstract
Comparison of the thrombophilic gene polymorphisms and recurrent pregnancy loss: Results on combined gene effect of FVLeiden, FVR2, FXIII, MTHFR(A1298C and C677T), PAI-1 4G/5G and ACE I/D genes in RPL Women from Misk/Belarus and Canakkale - Sivas/Turkey
Highlights
Recurrent pregnancy loss (RPL) is defined if a couple having consecutive loss of two or more pregnancies with the same partner before 20 weeks of gestation and not more than one living child [14]
RPL women are basicly classified into three groups as: women without previous 2 live birth, live birth after pregnancy losses, and pregnancy losses followed by a live birth [10]
Fetal, environmental and paternal based ethiological risk factors were reported in RPL pathogenesis [13,14,15]
Summary
Recurrent pregnancy loss (RPL) is defined if a couple having consecutive loss of two or more pregnancies with the same partner before 20 weeks of gestation and not more than one living child [14]. The RPL is a significant clinical problem with many etiologies. Inherited and/or acquired thrombophilia is an important contributing factor in unexplained RPL [5,6,7,8,9]. Some RPL couples have an additional parental associated genetic risk factors but some have non-genetic histories [11,12]. Fetal, environmental and paternal based ethiological risk factors were reported in RPL pathogenesis [13,14,15]. Inherited and/or acquired thrombophilic gene polymorphisms are the basic debated problems that may common acceptable in women with unexplained RPL [14,15,16]. Large amount of literature findings from different populations showed the incidence of specific thrombophilic gene polymorphisms in RPL women.
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