Comparison of the Three Sets of Diagnostic Criteria for Vogt–Koyanagi–Harada Disease in Southeast China – A Retrospective Case–Control Study

Abstract

ABSTRACT Purpose To compare the utility of the Chinese diagnostic criteria for Vogt–Koyanagi–Harada (VKH) disease (CDCV), the revised diagnostic criteria (RDC) and the classification criteria by SUN (SUN-C). Methods Two groups of patients (VKH group and non-VKH group) were assessed in this retrospective case–control study. Sensitivity, specificity and area under receiver operating characteristic curve (AUC) were evaluated among these criteria. Results 258 patients were included after propensity score matching. The sensitivities were 92.2% in CDCV, 66.7% in RDC, and 54.3% in SUN-C. In different disease stages (early and late), similar sensitivity results were observed. The specificities were 96.1% in CDCV, 97.7% in RDC, and 99.2% in SUN-C. The AUCs were 0.942 in CDCV, 0.822 in RDC and 0.767 in SUN-C. Conclusion A higher sensitivity value and larger AUC in CDCV were found. CDCV are highly useful in the diagnosis and classification of VKH disease in Chinese patients.