Comparison of the safety and efficacy of the on-demand use of sertraline, dapoxetine, and daily use of sertraline in the treatment of patients with lifelong premature ejaculation: A prospective randomised study.

Abstract

This study compared the safety and efficacy of the on-demand (OD) use of sertraline (50mg), sertraline (100mg) and dapoxetine (30mg), and the daily use of sertraline (50mg) in the treatment of patients with premature ejaculation (PE). This prospective randomised study involved 120 lifelong PE patients (intravaginal ejaculatory latency time [IELT]: <1min; Arabic Index of Premature Ejaculation [AIPE] score: < 30) without secondary causes of PE, identified between March 2018 and May 2020. Patients were divided into 4 groups (30 patients per group) and treated for 8weeks. Assessments were conducted using the AIPE form as a diagnostic tool. Sertraline (50mg, daily; 196.7±115.5s) and sertraline (100mg, OD; 173.3±97.0s) had similar IELT and AIPE scores. The latter groups had better results in comparison with sertraline (50mg, OD; 100.5±54.4s) and dapoxetine (93.7±53.5s; p<0.01). Sertraline (100mg, OD) had a similar efficacy to that of sertraline (50mg, daily) and was more effective than sertraline (50mg, OD) and dapoxetine (30mg, OD). Sertraline (100mg, OD) can be considered in the treatment of lifelong PE treatment, having tolerable side effects.