Abstract
To evaluate several cognitive parameters during the execution of behavioral tasks assessing cognitive function in laboratory animals, the parameters are reported within a range. This situation entails that each laboratory must establish the conditions under which the behavioral task to evaluate the cognitive function can be carried out. C57BL/6 and BALB/c inbred strains are used more often in behavioral studies relating to anxiety, stress, fear and cognitive function. The aim of this work was to compare the behavioral response of mice of the strains BALB/c and C57BL/6 to evaluate memory and learning as cognitive functions. Young male mice, 7–8 weeks of age, from each strain were used. Y maze, object recognition and passive avoidance tasks were performed. Both strains of mice showed differences in the response to the passive avoidance and Y maze task. This study advances knowledge about the baseline behavior of laboratory mice strains and their response during the experimental procedures, which are due to the treatment, genetic influence, procedural differences, genetic background variance, or any combination of these elements.
Highlights
A large number of tests have been developed to evaluate the improvement of cognitive function in laboratory animals that receive different pharmaceutical formulations [1,2,3]
The aim of this work was to compare the behavioral response of male mice of the strains BALB/c and C57BL/6 for evaluate memory and learning as cognitive functions
Task a trend showing that the spontaneous alternation was higher in C57BL/6strain compared to BALB/c, During alternation in spontaneous alternation(Figure in Y-test
Summary
A large number of tests have been developed to evaluate the improvement of cognitive function in laboratory animals that receive different pharmaceutical formulations [1,2,3]. These tests are known, indistinctly, like behavioral models or as behavioral tests. Other tests are used to evaluate spatial and working memory such as the T or Y-maze task sand the radial maze task, as well as non-spatial task of memory, as objects recognition task [5] Another group of tasks are based on associative learning as is the case of passive avoidance and active avoidance [6]. The aim of this work was to compare the behavioral response of male mice of the strains BALB/c and C57BL/6 for evaluate memory and learning as cognitive functions
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