Abstract
A careful study of some factors influencing LH secretion and storage has been made in immature and adult rats of both sexes. The ovarian ascorbic acid assay for LH has been utilized throughout. The LH content of the anterior lobe was 19.8 μg/gland in immature females and 22.3 μg/gland in adults. In immature males the content (7.0 μg /gland) was lower than that in immature females and rose markedly to a value of 32.9 μg/gland in adults, a value which was greater than that found in adult females. No detectable LH was found in plasma from rats with intact gonads except in the case of adult males, in which minimal levels were detectable. Two to 3 weeks following gonadectomy, pituitary LH content had risen significantly in both adult females and immature males, whereas it remained unchanged in immature females and adult males. By contrast with the variable response to gonadectomy seen in the hypophysis, plasma LH activity increased significantly in all gonadectomized groups. When expressed on a weight basis, e...
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