Abstract
BackgroundPrevious studies have validated the capability of SYNTAX score (SS) and clinical SYNTAX score (CSS) in the prediction of clinical outcomes in patients who have undergone PCI; however, studies on comparison of these two scoring systems in Chinese population have been sparse.MethodsTo study the ability of SS and CSS in prediction of clinical outcomes of Chinese patients underwent percutaneous coronary intervention (PCI). We retrospectively calculated SS and CSS for 547 Chinese patients from a single center who underwent PCI. Patients were stratified into tertiles according to their SS and CSS. We compared the 2-year clinical outcomes in these patients stratified separately by SS and CSS tertiles.ResultsThe incidence of major adverse cardiac and cerebro-vascular events (MACCE) was the highest in patients with SSHIGH (13.5%), comparing to 6.8% in SSMED and 0% in SSLOW (p < 0.0001). The Cox multivariable analysis showed that the SS and CSS were both strong independent predictors for MACCE [1.100 (1.069–1.133), 1.017 (1.010–1.025), both p < 0.0001]. The receiver operating characteristic (ROC) curves showed the areas-under-the-curves for all-cause death by CSS was slightly larger comparing to SS but not significantly (AUC SS, 0.64; AUC CSS, 0.71; p = 0.23).ConclusionWe concluded that both the SS and CSS were capable of risk stratification of clinical outcomes in all-comers population as well as in low and moderate risk Chinese patients undergoing PCI with CSS showing slightly better advantage.
Highlights
Previous studies have validated the capability of SYNTAX score (SS) and clinical SYNTAX score (CSS) in the prediction of clinical outcomes in patients who have undergone percu‐ taneous coronary intervention (PCI); studies on comparison of these two scoring systems in Chinese population have been sparse
SS does not take into account of other clinical factors, such as those included in the ACEF score, which could significantly impact the prediction of prognostic outcomes [12,13,14]
These risk scoring models were more frequently used in high risk (3-vessel and/or left main coronary artery disease) patients treated by PCI, few studies included a study population composed of a majority of low and moderate risk patients
Summary
Previous studies have validated the capability of SYNTAX score (SS) and clinical SYNTAX score (CSS) in the prediction of clinical outcomes in patients who have undergone PCI; studies on comparison of these two scoring systems in Chinese population have been sparse. CSS had been shown to improve the predictive ability for adverse clinical outcomes in patient underwent PCI [15, 16] These risk scoring models were more frequently used in high risk (3-vessel and/or left main coronary artery disease) patients treated by PCI, few studies included a study population composed of a majority of low and moderate risk patients. Among 1.4 billion Chinese people, the vast majority (1.3 billion) belong to the Han people, which is the world’s largest ethnicity This situation is very different from other countries, like the US, where multiple ethnicities make up considerable percentages of the total population. Due to this huge population base and the domination of Han people, most populationbased studies need to be tested in Chinese-dominated population to prove their applicability to Chinese people
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