Abstract
Background: Cyclosporine and Tacrolimus are two main immunosuppressants of kidney transplant patients and are commonly used in hospitals with renal transplantation.
 Aim of the study: The goal of this study is to demonstrate potential harmful effects, not only from kidney failure as a disease, but also the use of immunosuppressants before and after renal transplants.
 Materials and Methods: An analysis of tacrolimus or cyclosporine immunosuppressive regimes has been conducted in Baghdad hospital using data from patients with kidney transplants. The study excluded patients who received other types of immune suppressant drugs, and those who switched from cyclosporine to tacrolimus. 
 Conclusion: Effectiveness and side effects should be tested in kidney transplantation patients with cyclosporin and tacrolimus and other immunosuppressive medications, tacrolimus treated patient has shown an increase in glucose level and decrease in WBC , hemoglobin and calcium level in comparing to cyclosporine treated group.
 
 This finding may allow scientists and physicians to make a better choice between immunosuppressive drugs according to the patient's medical condition.
Highlights
Chronic kidney disease [CKD] is a major threat to public health with a rapid rise in its global prevalence and occurrence, in the developing countries, resulting in end-stage renal disease [ESRD], premature mortality, poor quality of life and large health systems burden
Tacrlimus and cyclosporine are thought to contributed to Hyperglycemia through a variety of mechanism, including the inducement of insulin resistance coupled with direct beta cell effects, The differential impact of individual immunosuppressive agents on incidence of PTDM[ post-transplant diabetes mellitus ] and glycemic control has been examined
Bouchta et al studied patients who developed PTDM following renal transplantation and were converted from tacrolimus to cyclosporine, he found that Tacrolimus conversion to cyclosporin for PTDM is associated with a significant improvement in glucose metabolism and frequent reversal of diabetes [11]
Summary
Chronic kidney disease [CKD] is a major threat to public health with a rapid rise in its global prevalence and occurrence, in the developing countries, resulting in end-stage renal disease [ESRD], premature mortality, poor quality of life and large health systems burden. As an end result of the rise in non-communicable diseases, the number of patients with end stage kidney disease [ESKD] is growing worldwide. Conclusion: Effectiveness and side effects should be tested in kidney transplantation patients with cyclosporin and tacrolimus and other immunosuppressive medications, tacrolimus treated patient has shown an increase in glucose level and decrease in WBC , hemoglobin and calcium level in comparing to cyclosporine treated group. This finding may allow scientists and physicians to make a better choice between immunosuppressive drug s according to the patient's medical condition
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