Abstract
Serum protein electrophoresis (SPE) and total immunoglobulin measurements are recommended to quantify monoclonal immunoglobulins (M-Ig) for monitoring multiple myeloma (MM) patients. However SPE measurements may be inaccurate at low M-Ig concentrations or when the M-Ig co-migrates with other serum proteins. Total IgA (tIgA), although accurate, cannot distinguish between monoclonal and polyclonal immunoglobulin components. Novel heavy/light chain immunoassays (HLC) may provide an alternative method to accurately quantify M-Ig. Here we assess the performance of these assays for monitoring MM patients.
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