Comparison of the performance of magnetic targeting drug carriers prepared using two synthesis methods.

Zhen Shi,Shaobo Dong,Tianyu Lan,Yazhen Wang

doi:10.1039/d1ra04256d

Abstract

In this paper, two methods were used to prepare the magnetic targeting drug carrier Fe3O4–PVA@SH, the step-by-step method and the one-pot method. The loading and release properties of the compound were measured. The results show that the Fe3O4–PVA@SH prepared using both methods exhibited excellent drug delivery properties in an environment that simulates human body fluid (pH 7.2) and a lysosomal in vitro simulation (pH 4.7). In applications such as drug delivery, magnetic targeted drug carriers prepared by both methods demonstrated superparamagnetism, high fat solubility, high hydroxyl content, and good water solubility.

Highlights

As more interdisciplinary work is conducted in the elds of nanotechnology and pharmacology, magnetically targeted drug delivery systems have attracted increasing interest
By using modi ed magnetic particles as drug carriers and enriching magnetic drug particles in the lesion, the loaded drug is released in a controlled manner to achieve targeted therapy
The magnetically targeted drug delivery system achieves the four-fold objective of synergism, toxicity reduction, controlled release, and gradual release.[3,4]

Summary

Introduction

As more interdisciplinary work is conducted in the elds of nanotechnology and pharmacology, magnetically targeted drug delivery systems have attracted increasing interest. New opportunities have become available in general and applied research on biomedical diagnostics and therapeutics through the recent development of small-size, high-saturation magnetization strength, superparamagnetic, and surfacemodi ed magnetic nanoparticles.[5,6,7] The size of these magnetic nanoparticles are comparable to viruses (20–450 nm), proteins (5–50 nm), DNA, and genes (2 nm and 10–100 nm long).[8,9] when used as magnetic targeting drug carriers, these nanoparticles are capable of entering the target site of a diseased organ or tissue as well as the interior of tumour cells.[10,11,12,13] For example, by loading adriamycin (DOX)

Methods

Results

Conclusion