Comparison of the ocular perfusion pressure fluctuation between medically controlled and operated eyes with glaucoma

Abstract

Purpose: To compare the fluctuation of the OPP between eyes treated with glaucoma medication and eyes with a functioning filtering bleb. Design: cross-sectional controlled paired-eye design. Methods: Fourteen patients with POAG with one eye operated on (trabeculectomy) and the fellow eye treated with medication enrolled the study. Blood pressure and intraocular pressure were measured at 7 a.m., 1 p.m., and 7 p.m. Systolic, diastolic and mean OPP were calculated for the three time points and the fluctuation (range between the highest and the lowest values) compared between the eyes. Results: Mean values of the mean OPP fluctuation were 7.2 ± 3.9 mmHg and 8.5 ± 4.0 mmHg, for operated eyes and medically treated eyes, respectively (P = 0.149); mean systolic OPP fluctuation was 20.7 ± 11.2 mmHg for operated eyes and 21.2 ± 11.7 mmHg for medically treated eyes (P = 0.478); the mean diastolic OPP fluctuation was 8.4 ± 4.4 mmHg for operated eyes and 10.5 ± 5.4 mmHg for medically treated eyes (P= 0.085). Conclusion: In this small cohort of patients with POAG the mean, systolic and diastolic OPP fluctuation did not differ between the operated eyes and medically treated ones. Financial disclosure: none.