Abstract
The applicability of suspensions of rat hepatocytes as the metabolic factor in a bacterial mutagenicity test was studied. Therefore, mutagenicity of 4-aminobiphenyl and benzidine towards the Salmonella typhimurium strains TA1538 and TA100 in the presence of rat-hepatic microsomal preparations or intact liver cells was measured. The mutagenic potency of these compounds was also established in the intrasanguineous host-mediated assay. Comparison of the test results showed that the mutagenic activity of 4-aminobiphenyl and benzidine after metabolism by intact rat hepatocytes resembled the mutagenic activity of these compounds after biotransformation in vivo more than after activation with a rat-liver S9 fraction.
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