Abstract
The oral cavity is one of the most complex microbial environments; however, the complex nature of the salivary microbiota and the level of inorganic anions in the saliva of subjects with and without gastroesophageal reflux disease (GERD) are poorly understood. The primary goals of this pilot research were to assess differences in salivary bacterial community composition and inorganic anion concentrations between patients with GERD and GERD-free people. Thus, the salivary microbiota within both groups was dominated by these genera: Streptococcus, Prevotella, Porphyromonas, Veillonella, Neisseria, Haemophilus, Fusobacterium, Rothia, and Leptotrichia. However, the relative abundances of the genera Actinomyces, Atopobium, Stomatobaculum, Ruminococcaceae_[G-2], Veillonella, and Leptotrichia were significantly higher in the saliva samples of patients with GERD, while the genera Porphyromonas, Gemella, Peptostreptococcus, and Neisseria were less abundant in this group. The concentrations of chloride, phosphate, and sulphate ions in the human saliva varied among all subjects and sampling time. These results broaden our knowledge of the salivary microbial community composition and chemistry of saliva of patients with GERD and GERD-free individuals.
Highlights
The oral cavity is one of the most complex microbial environments colonized by a set of microorganisms that play an essential role in maintaining oral homeostasis [1]
In the research described we used a 16S rRNA gene Illumina sequencing approach to characterize the salivary microbiota of people with gastroesophageal reflux disease, which has not been previously studied well
We showed that the bacterial community structure of the salivary microbiota of people with gastroesophageal reflux disease (GERD) was slightly different from those of people without GERD
Summary
The oral cavity is one of the most complex microbial environments colonized by a set of microorganisms that play an essential role in maintaining oral homeostasis [1]. A deep understanding of the pathogenic mechanisms that influence the development of various diseases is extremely important. The development of oral biofilms is affected by different factors, including environmental and behavioral factors and the host’s immune response to colonization by microorganisms. The immune factors of the host, especially those detected in saliva, can affect susceptibility to oral diseases. Saliva contains a mixture of innate antimicrobial proteins and adaptive immune mediators, which can have a BioMed Research International
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