Comparison of the mass and amount of intramuscular non-contractile tissue of the trunk and lower extremity muscles between patients with Parkinson's disease and community-dwelling older adults.

Abstract

This study compared the masses and amounts of intramuscular non-contractile tissue of the trunk and lower extremity muscles, sagittal spinal alignment, and mobility and balance ability between patients with Parkinson's disease (PD) and older adults. This study included 26 older adults (control [CTR] group) and eight patients with PD (PD group). Muscle thicknesses and echo intensities of the trunk and lower extremity muscles were measured using an ultrasound imaging device. Sagittal spinal alignments in the standing and prone positions were assessed using a Spinal Mouse. Mobility capacity was assessed based on the measurements of usual and maximal walking speeds, timed up-and-go (TUG) time, and five-chair-stand time, while balance ability was assessed based on the measurement of one-legged stance (OLS) time. Our results showed significantly lower gluteus maximus and tibialis anterior muscle thicknesses, higher thickness of the short head of the biceps femoris muscle, and higher echo intensity of the gluteus maximus muscle in the PD group than in the CTR group. Lumbar lordosis angle in the standing position, usual and maximal walking speeds, and OLS time were significantly lower, while the TUG and five-chair-stand times were significantly higher in the PD group than in the CTR group. The other factors did not differ significantly between groups. Our results revealed lower masses of the gluteus maximus and tibialis anterior muscles, higher mass of the short head of the biceps femoris muscle, and higher amounts of intramuscular non-contractile tissue of the gluteus maximus muscle in patients with PD.