Abstract
Aging is a major risk factor for many diseases, including cardiovascular diseases, neurological disorders, cancer and diabetes mellitus. Oxidative stress plays a key role in the aging process. Amauroderma rugosum is an edible mushroom that has rarely been studied. The aims of this study were to compare the major chemical constituents and to investigate the antioxidant effects of Amauroderma lucidum and Ganoderma lucidum. The water extract of Amauroderma lucidum contained a higher amount of total phenolic compounds than that of Ganoderma lucidum. The total polysaccharide and triterpene content in water extracts of Amauroderma rugosum and Ganoderma lucidum did not significantly differ. The water extract of Amauroderma rugosum demonstrated free radical scavenging capacity and could reduce doxorubicin-induced damage in H9c2 cardiomyoblasts. Amauroderma rugosum has stronger antioxidant and cellular protective effects than Ganoderma lucidum. Amauroderma rugosum may be beneficial in healthy aging, and further study should be encouraged
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