Comparison of the in vivo antifungal activity of amphotericin B-Solulan C24, amphotericin B-Myrj 59 and amphotericin B-Synperonic A50 with fungizone

Abstract

Three associations of amphotericin B with the surfactants, Solulan C24, Myrj 59 and Synperonic A50, were compared with the commercial preparation, Fungizone (amphotericin B-sodium deoxycholate), in treating systemic candidiasis in NMRI male mice. Following an intravenous injection, there was no difference between the four treatment groups in the survival of infected animals. When amphotericin B was injected intraperitoneally, the associations with Myrj 59 and Synperonic A50 were as active as Fungizone but that with Solulan C24 was shown to be more active.