Comparison of the imaging effects of SonoVue and Sonazoid at high frequency in rabbit-liver ultrasonography

Abstract

Objective To compare the contrast enhancement effects of SonoVue and Sonazoid in rabbit liver at ultrasonic frequency of 7 MHz using various mechanical index(MI) and dosage. Methods Eight rabbits were bolus injected with different contrast agents:for SonoVue(0. 06 ml/kg,0. 12 ml/kg) ,MI ranging 0. 10 - 0. 55; while Sonazoid (0. 045 ml/kg, 0. 09 ml/kg) , MI ranging 0. 19 - 0. 98. Quantitative analysis of ultrasonography was done using video-intensity analysis system, and peak intensity (PI) was compared. Results With the same frequency, in SonoVue group, for both dosage groups, PI reached maximum at MI = 0. 15 ( P <0. 05) ; with the same MI, PI of the high dosage group was higher ( P < 0. 05). In Sonazoid group,for both dosage groups,PI reached maximum at MI = 0. 40( P <0. 05) ; with the same MI,PI of the high dose group was higher ( P <0. 05). Conclusions The optimistic ultrasonographic conditions provided to SonoVue and Sonazoid are different. Dosage of contrast agents, MI and frequency need to be concerned. Key words: Ultrasonography; Microbubbles; Liver