Abstract
Elizabethin is a pentaene polyene recently isolated from cultures of Streptomyces elizabethii. A comparison was made between the effects of amphotericin B and elizabethin on the viability and turbidity of stationary phase cells of Candida pseudotropicalis suspended in either growth medium or phosphate buffer. The inhibitory effect of amphotericin B on cells suspended in growth medium was only observed at a time when control cultures were at the end of the lag phase. However, elizabethin caused rapid cell death even when control cultures were still in the lag phase of growth. Elizabethin, unlike amphotericin B also caused rapid death and lysis of non-growing, stationary phase cells suspended in phosphate buffer.
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