Abstract
This study aims to compare the effects of different inhalation anesthetics on oxidative status by measuring thiol-disulfide homeostasis in laparoscopic cholecystectomy surgeries. The effect of inhaler agents on thiol-disulfide homeostasis that shows the oxidative status in laparoscopic cholecystectomy is unknown. In this study, 71 patients planned to undergo laparoscopic cholecystectomy under general anesthesia were included. They were divided into two groups: desflurane (group D, n: 35) and sevoflurane (group S, n: 36). Blood samples were taken before induction (T1), at 30th minute of insufflation (T2) (30th min of ischemia), and at 30th min postdeflation (T3) (30th min of reperfusion). The native thiols (-SH) and total thiols (-SH+ -SS) were determined. The amounts of disulfide (-SS), disulfide/native thiol percent ratios (-SS/-SH), disulfide/total thiol percent ratios (-SS/-SH+-SS), and native thiol/total thiol percent ratios (-SH/-SH+ -SS) were calculated. In the sevoflurane group, preoperative values and intraoperative 30th-minute SS-SH ratio were significantly reduced (p=0.017). In the desflurane group, intraoperative native thiol values and postdeflation levels significantly decreased compared to those in the preoperative values (p<0.001). We think that the usage of sevoflurane was more protective in terms of the oxidative damage occurring during laparoscopic surgery.
Highlights
Due to its advantages, laparoscopic cholecystectomy has become a common procedure
Objective: This study aims to compare the effects of different inhalation anesthetics on oxidative status by measuring thiol-disulfide homeostasis in laparoscopic cholecystectomy surgeries
We aimed to investigate the effect of general anesthetic drugs such as sevoflurane and desflurane on thiol-disulfide homeostasis in patients undergoing laparoscopic cholecystectomy
Summary
Laparoscopic cholecystectomy has become a common procedure. The gastric pH values were measured to determine oxidative status [2, 3]. One of these methods is to measure the thiol disulfide balance. Erel et al [4] have succeeded in measuring this balance through thiol disulfide hemostasis. Given the advances in technology, it is obvious that a number of abdominal surgical procedures can be performed with laparoscopic or robotic surgery. The effects of anesthetic volatile agents on oxidative and cytotoxic mechanisms have been previously studied, but their effects on thiol-disulfide homeostasis has not yet been investigated [5]
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