Abstract

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy in adulthood. Temporal lobe plays a central role in the regulation of cardio-autonomic functions (CAF) which can be also influenced by several anti-seizure therapies. The spectral analysis of the Heart Rate Variability (HRV) represents a useful tool for the evaluation of CAF. The aim of this study is to assess, using the spectral analysis of HRV, new anti-seizure medication (ASMs) - Perampanel (PER), Lacosamide (LCS), Eslicarbazepine (ECB) and Brivaracetam (BRV) - effects on CAF in patients with TLE.

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