Abstract
Cohen, Marinello and Back1 (1967) first reported that lysergic acid diethylamide (LSD) increased chromosome abnormalities in human leucocytes. Although some later work failed to support this observation2–4, others have confirmed that LSD damages chromosomes5–10. I have investigated the dose–effect relationship of LSD and the type of damage produced in chromosomes of leucocyte cultures of the marsupial Potorous tridactylus (rat-kangaroo), which has a few large chromosomes (2 n = 12 in ♀ and 13 in ♂) that make scoring of damage relatively easy and accurate.
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