Abstract
In children acute severe asthma is a serious condition. The inhaled route for drug delivery is not appropriate when only small respiratory gas volumes are shifted; the i.v. route may be associated with greater side effects. Magnesium sulphate IV has a place in acute asthma management because it is a mild bronchodilator, and has a stabilizing effect on the atria.
 Objective: To compare the effectiveness of intravenous magnesium sulphate versus intravenous aminophylline in acute attack of asthma.
 Study Design: Randomized control trial.
 Setting: Emergency Department of pediatric
 Duration: April 2017 to October 2017.Material & Methods: 60
 cases were included in the study. They were randomly divided in two comparable groups. Children in group A ware treated with intravenous magnesium sulphate and group B with intravenous aminophylline. The efficacy of the drug was judged by the improvement in the sign observed like respiratory rate (less than 40 per minute), pulse rate(<100), oxygen saturation( above 90 %) assessed after the time period of three hours.
 Results: Effectiveness of intravenous magnesium sulphate in acute attack of asthma was found in 28 cases in Group A (93.33%) and in 22 cases in Group B (73.33%) with p-value 0.03. However, 6.67% cases (2 cases) in Group A and 26.67% cases (8 cases) in Group B did not show effectiveness.
 Conclusion: The clinical efficacy of intravenous magnesium sulphate in managing case of acute severe asthma was better when compared with intravenous aminophylline.
Highlights
Asthma is a common chronic airways problem of children and they comprise 7-10% of the population
Children in group A were treated with IV magnesium sulphate with a (50-70 mg/kg/dose given in 30 minutes) and cases in group B were treated with IV aminophylline (5mg/kg/dose given in 30 minutes)
A total of 60 cases (30 in each group) fulfilling the inclusion/exclusion criteria were enrolled to compare the effectiveness of IV magnesium sulphate versus IV aminophylline in acute attack of asthma
Summary
Asthma is a common chronic airways problem of children and they comprise 7-10% of the population. The overall deaths were 4210/year.[2] Magnesium sulfate has been widely used in anesthesia, Obstetrics and Intensive care unit It is considered a combination therapy for severe asthma exacerbations.3It is postulated to interfere physiological action of calcium resulting in decreased bronchial smooth muscle contraction. Objective: To compare the effectiveness of intravenous magnesium sulphate versus intravenous aminophylline in acute attack of asthma. Children in group A ware treated with intravenous magnesium sulphate and group B with intravenous aminophylline. Results: The improvement after intravenous magnesium sulphate in severe attack of asthma was found in 28 cases in Group A (93.33%) and in 22 cases in Group B (73.33%) treated with intravenous aminophylline ( p-value 0.03). Conclusion: The clinical efficacy of intravenous magnesium sulphate in managing case of acute severe asthma was better when compared with intravenous aminophylline
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