Abstract
The effects of (±) CP 96,345 and L-668,169 on NK 1-, NK 2- and NK 3-receptor mediated contractile responses were compared in guinea-pig and rat isolated smooth muscle tissues. Both (±) CP 96,345 and L-668,169 inhibited NK 1-mediated responses in guinea-pig ileum (pA 2 = 9.3 and 6.4 respectively) but not in rat bladder (pK B = < 6 and < 5.5 respectively) consistent with species differences in NK 1-receptor pharmacology. Both compounds showed some selectivity in inhibiting NK 1-receptor evoked responses in guinea-pig ileum compared to their inhibitory effects on NK 2-receptor mediated responses in guinea-pig bladder and rat ileum and NK 3-mediated responses in guinea-pig ileum and rat portal vein.
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