COMPARISON OF THE EFFECTS OF CLINICOPATHOLOGICAL AND RADIOLOGICAL FINDINGS ON SURVIVAL IN WOMEN YOUNGER THAN 40 YEARS AND OLDER THAN 55 YEARS OF AGE WITH BREAST CANCER

Abstract

Objective
 Tumors of women with breast cancer show clinical
 and biological differences depending on the hormonal
 changes that develop with age. Therefore, in this study,
 we compared the radiologic, and clinicopathological
 features of breast cancer patient’s < 40 age and ≥55
 age.
 Material and Method
 The files of a total of 759 patients, including 92
 patients under 40 aged, and 322 patients 55 aged and
 over who were operated on for breast cancer over a
 10-year period in three centres were retrospectively
 reviewed and Estrojen Reseptor (ER), Progesteron
 Reseptor (PR), Human epidermal growth factor
 receptor 2 (HER2), Lymphovascular invasion (LVI)
 status, presence of axillary lymph node metastasis
 (ALNM), multifocality, presence of Ductal Carsinoma
 İnsitu (DCIS) or Lobular Carsinoma İnsitu (LCIS),
 tumor size, tumor histopathological type, grade, and
 score were recorded.
 Results
 In patients under the age of 40, the tumor is less
 localized in the upper-inner and lower-inner quadrants
 of the breast, multifocality is more common, most of
 them have dense breast structure, the histological
 grade of the tumor is higher, LVI and LNM are more
 common. It was found that they had ER receptor
 positivity and higher Ki-67 proliferation index (p