Abstract

Twenty-five epileptic outpatients were studied to assess possible effects of the first 6 months of treatment with carbamazepine or ox- carbazepine using serial peripheral nerve conduction measurements. Carbamazepine caused a small slowing effect on the motor con- duction of the median nerve after 4 weeks of treatment, and the effect was correlated with the fasting serum concentration of the drug. Slowed motor conduction value of the median nerve was also observed after 6 months of treatment with carbamazepine. Oxcarbaze- pine did not cause any statistically significant slowing of nerve conduction.

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