Comparison of the effectivenessof 4 anti-inflammatory drops in relieving photophobia after pupil dilation

Abstract

Purpose: To compare the relative effectiveness of diclofenac, flurbiprofen, ketorolac, and prednisolone acetate in relieving photophobia after pupil dilation for fundus examination. Setting: Eye, Ear, Nose, and Throat Hospital, New Orleans, Louisiana, USA. Methods: This prospective, blind, placebo-controlled study comprised 105 patientsrandomly assigned to 1 of 10 treatment groups. Five minutes after instillation of dilating drops, each patient received drops of different test medications in the right and left eyes. Light sensitivity and pupil measurement tests were performed over 2 hours after the pharmacological mydriasis. After photostimulation, patients were asked to rate their photosensitivity on numerical and analog scales and to indicate a filter value required to alleviate light-induced discomfort. Test results were analyzed to detect differences among the pain levels associated with each treatment. Results: There were no significant differences between the placebo and any activetreatment drug at any time during the study. Conclusion: These findings suggest that mediators other than prostaglandins mayhave a role in photosensitivity or that increased postmydriatic photosensitivity is a result of higher light levels entering the eye through the dilated pupil.