Abstract
Diabetes Mellitus is a disease characterized by hyperglycemia or the glucose in the blood increased or beyond ordinary. The national prevalence of Diabetes Mellitus in Indonesia is 6,9%. Patients with Diabetes Mellitus can be given antidiabetic drugs such as sulfonylurea and glinid. The antidiabetic drug can be consumed as a combination or single. This study aims to determine whether there is a significant efficacy comparison between antidiabetic combination therapy and single antidiabetic therapy. This study is a retrospective casual research by looking at the medical record. From 30 patients, 15 patients using oral antidiabetic combination therapy and 15 patients using oral antidiabetic single therapy, there were mean differences on the first day where patients using oral antidiabetic single therapy mean 228,47 and patients using oral antidiabetic combination therapy mean 294,07. There is no significant difference between single antidiabetic therapy or antidiabetic combination therapy from the statistic test.
 Keywords: Diabetes, Antidiabetic effectiveness
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