Abstract
Candidal vaginitis has a relatively high prevalence, and its resistance to treatment is on the rise. Considering the complications of chemical drugs, the use of herbal medicines has now been favored due to the lack of changes in the normal vaginal flora. The aim of this study was to compare the effectiveness of Satureja khuzestanica and clotrimazole vaginal creams for the treatment of candidal vulvovaginitis. A randomized clinical trial was conducted on 84 reproductive-aged women in the city of Ahvaz, Iran. Individuals were randomly divided into two treatment groups: 1% Satureja khuzestanica vaginal creams (n=42) and 1% clotrimazole vaginal cream (n=42) who used a one-full applicator daily for one week. About 4–7 days after the end of treatment, a clinical examination and laboratory re-tests were performed to determine the level of treatment. The data were analyzed using the Mann-Whitney U, t-test and Chi-square tests, with SPSS version 22. After the treatment, no significant difference was observed between the two groups in terms of vaginal discharge (p = 0.32), vaginal itching (p = 0.26), dysuria (p = 0.99) and dyspareunia (p = 0.60). Moreover, the results of culture (p = 0.62) and smear (p = 0.58) were not statistically significant in the two groups. Also, there was no significant difference between the two groups in terms of complete recovery after the treatment (p = 0.35). Satureja khuzestanica seems to have the same effect as clotrimazole in improving the symptoms of vaginal candidiasis, the negative results of culture and smear, as well as complete treatment.
Highlights
Genital tract infection is one of the most common causes of women’s visits to treatment centers
Candida albicans is responsible for 85–90% of vaginal candidiasis and has more ability to stick to vaginal epithelial cells than other Candida species [4]
The aim of this study was to compare the effect of Satureja khuzestanica and clotrimazole vaginal creams on the treatment of vulvovaginal candidiasis
Summary
Genital tract infection is one of the most common causes of women’s visits to treatment centers. Candidal vaginitis is the second most common cause of vaginitis in women and is diagnosed in more than 40% of women in health centers [1]. Women develop vaginal candidiasis at least once (75%) or twice (50%) in their lives, and 5% of most women develop it more than four times a year [2, 3]. Other types of Candida, such as Candida glabrata and Candida tropicalis, which cause vaginal candidiasis, are usually resistant to treatment [5]. Their prevalence has been reported between 25–45% [6, 7]
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