Abstract
This study compares the effect of Hyalobarrier Gel and 4DryField® PH on the formation of postoperative adhesions after myomectomy in an experimental study on rabbit does. Thirty experimental animals were divided into three groups: group A – control, group B – use of 4DryField® PH, and group C – use of the Hyalobarrier Gel. A simulated myomectomy was performed in each group. The animals were euthanised 14 days after the procedure and the antiadhesive effect of the above-mentioned preparations was evaluated according to the criteria. Statistical evaluation clearly showed differences in the antiadhesive effect in the scoring systems for groups B and C compared to control group A at a high level of significance. We demonstrated an obvious, statistically confirmed antiadhesive effect of the Hyalobarrier Gel and 4DryField® PH in an experimental model of the rabbit uterus. Comparing both preparations, the Hyalobarrier Gel shows a higher level of effectiveness. Based on the results of the experiment, both preparations can be unambiguously recommended for routine practice.
Highlights
The rabbit uterus duplex model is often used in experimental surgery for the relative availability of the experimental animal, favourable anatomical conditions, and frequent
Hyalobarrier gel, Padova, Italy) and 4DryField® PH (4DryField; PlantTec Medical GmbH, Lüneburg, Germany) after simulated myomectomy that we did not find in the available literature on a rabbit uterus duplex model
Statistical significance was evaluated using Mann Whitney U test for continuous variables and Fisher exact test for categorical variables
Summary
The rabbit uterus duplex model is often used in experimental surgery for the relative availability of the experimental animal, favourable anatomical conditions, and frequent. Address for correspondence: MVDr. Andrea Nečasová Department of Surgery & Orthopaedics Small Animal Clinic Faculty of Veterinary Medicine University of Veterinary and Pharmaceutical Sciences Brno Palackého tř. 1946/1, 612 42 Brno, Czech Republic postoperative adhesions (D u n n et al 2001; Müller et al 2011). An experimental study was performed, comparing the antiadhesive effect of the Hyalobarier Gel (Anika Therapeutics S.r.l. Hyalobarrier gel, Padova, Italy) and 4DryField® PH (4DryField; PlantTec Medical GmbH, Lüneburg, Germany) after simulated myomectomy that we did not find in the available literature on a rabbit uterus duplex model
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