Abstract
The effect of a series of trihalomethanes, CHCl 3, CHBrCl 2, CHBr 2Cl, and CHBr 3, on in vitro lipid metabolism was compared using rat liver slices. The incorporation of 32Pi and [ 3H]glycerol into phospholipid of liver slices was inhibited in the presence of trihalomethanes. The inhibitory effect followed the number of bromine atoms in the trihalomethane molecule in the initial period of incubation. CHBr 3 markedly inhibited the incorporation of [ 3H]glycerol into triacylglycerol (TG); CHBr 2Cl was less effective and the other two trihalomethanes were without effect. The activities of glycerophosphate acyltransferase, phosphatidate phosphatase and diacylglycerol acyltransferase were changed by the exposure to trihalomethanes. The effects of CHBr 2Cl and CHBr 3 were much more severe as compared to those of CHBrCl 2 and CHCl 3. The change in the enzyme activities could explain the alteration in the incorporation of [ 3H]glycerol into TG.
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