Abstract
Caerulein, desulfated caerulein, the octapeptide of cholecystokinin, cholecystokinin, and pentagastrin were compared for stimulation of acid secretion from Heidenhain pouches in dogs. Pentagastrin and desulfated caerulein evoked similar maximal rates of secretion. Caerulein and octapeptide of cholecystokinin elicited similar dose-response curves and the maximal secretory rates with these two peptides were less than 50 per cent of that of pentagastrin. Cholecystokinin failed to stimulate pouch secretion over a wide range of doses. When cholecystokinin was added to an infusion of caerulein, acid secretion was inhibited. We interpret these findings as follows: (1) sulfation of tyrosyl in position 7 from the C-terminus in peptides with the active center of gastrin is the essential feature which changes these compounds from full agonists to partial agonists for gastric secretion in dogs; (2) the difference between natural cholecystokinin and the synthetic octapeptide of cholecystokinin for acid secretion probably is due to an enterogastrone other than cholecystokinin or secretin in the cholecystokinin preparation.
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