Abstract
1. 1. A partially purified fraction SVc and a purified homogeneous polypeptide SV III were isolated from the scorpion ( Buthus Martensii Kashi ) venom, collected in Shan Dong Province of China. SVc decreased the RCR, ADP/0 and Qo 2 of the rat brain mitochondria. It also decreased the cytochrome oxidase activity and increased the membrane lipid fluidity of the mitochondria. 2. 2. Effect of scorpion venom on the rat heart mitochondria was somewhat different from that of rat brain mitochondria. SVc also decreased RCR, ADP/0 and increased the membrane lipid fluidity of heart mitochondria. However, the Qo 2 and cytochrome oxidase activity were increased. 3. 3. SV III has a similar effect on the rat brain and heart mitochondria, but its concentration used is only 1 10 of the effective concentration of SVc.
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